Name: Hugh Hendrie, MB, ChB, DSc
Phone Number: (317) 423-5633
E-Mail
Secretary Name: Roberta Manns
Secretary Phone Number: (317) 423-5633
FAX: (317) 423-5695

RESEARCH INTERESTS

Dr. Hendrie leads a multi-disciplinary group who are conducting international comparative studies of dementia and Alzheimer's Disease in Nigeria and the United States. He is also collaborating with Dr. Christopher Callahan in intervention trials for the treatment of depression and dementia in primary care.  In addition, with Dr. Mary Austrom and Dr. Teresa Damush, he is conducting surveys of retired physicians and their spouses focusing on predictors of life satisfaction.

EDUCATION/TRAINING

INSTITUTION AND LOCATION DEGREE YEAR FIELD OF STUDY
University of Glasgow, Faculty of Medicine M.B. Ch.B. 1958
Wayne State University, Detroit, MI M.S. 1968 Biochemistry
Fellow, Royal College of Physicians, Canada 1967 Psychiatry
Visiting Professor, Cambridge Univ. w/Sir M. Roth 1983 Dementia
Doctor of Science in Medicine, University of Glasgow D.Sc. 2002  

ACADEMIC AND PROFESSIONAL POSITIONS

1975-2000 Chairman, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 
1977-2000 Albert Eugene Sterne Professor of Clinical Psychiatry, Indiana University
1987-Present Co-Director, Center for Alzheimer's Disease and Related Neuropsychiatric Disorders, Indiana University School of Medicine, Indianapolis
2000-Present Professor, Department of Psychiatry, Indiana University School of Medicine, Indianapolis
2001-Present Research Scientist, Regenstrief Institute for Health Care, Indianapolis, IN
2001-Present Center Scientist, Indiana University Center for Aging Research, Indianapolis, IN

HONORS

1975 Special Award for Teaching, Elected by Psychiatry Residents, Lafayette Clinic, Detroit, Michigan
1982 Alpha Omega Alpha Honor Medical Society, Elected as Faculty Member, Indiana University School of Medicine, Indianapolis, Indiana
1984-85 Outstanding Teacher, Elected by Senior Medical Students, Indiana University School of Medicine, Indianapolis, Indiana
1987 Certificate of Appreciation for Distinguished Support and Service, Alzheimer's Disease and Related Disorders Organization, Indianapolis, Indiana
1991 Nancy C.A. Roeske, M.D., Certificate of Excellence in Recognition of Outstanding and Sustained Contributions to Medical Education while at Indiana University, The American Psychiatric Association, New Orleans, LA
1992 Norman Skole Service Award, Mental Health Association in Marion County, Indianapolis, IN
1993 Alpha Omega Alpha Honor Medical Society Elected as President, Indiana University School of Medicine, Indianapolis, Indiana
1994- 97 Board of Directors, Alzheimer's Disease and Related Disorders Association, Inc., Central Indiana Chapter
1997 - Member, Advisory Committee, Alzheimer's Disease and Related Disorders Association, Inc., Central Indiana Chapter
2000 John W. Ryan Award for Distinguished Contributions to International Programs and Studies, Indiana University
2000 Sagamore of the Wabash, State of Indiana
2005 Senior Investigator Award, American Association for Geriatric Psychiatry
2005

Medical Research Honoree, Alzheimer's Association's Rita Hayworth Gala, Chicago

2007 Jack Weinberg Memorial Award in the field of Geriatric Psychiatry, American Psychiatric Association

CURRENT AND RECENT FUNDING

SELECTED PUBLICATIONS

  1. Hendrie HC, Gao S, Hall KS, Hui SL & Unverzagt FW. The Relationship between Alcohol Consumption, Cognitive Performance and Daily Functioning in an Urban Sample of Elderly African Americans. JAGS 1996;44:1158-1165.
  2. Ogunniyi A, Gureje O, Baiyewu O, Unverzagt FW, Hall KS, Oluwole S, Osuntokun BO and Hendrie HC. Profile of dementia in a Nigerian Community - types, pattern of impairment and severity rating. J Nat Med Assoc 1997;89(6):392-6.
  3. Sahota A, Yang M, Gao S, Hui SL, Baiyewu O, Gureje O, Oluwole S, Ogunniyi A, Hall KS and Hendrie HC. Apolipoprotein E - Associated Risk for AD in the African-American Population in Genotype Dependent. Ann Neurol 1997;42:659-661.
  4. Class CA, Unverzagt FW, Gao S, Sahota A, Hall KS and Hendrie HC. The Association Between APOE Genotype and Depressive Symptoms in Elderly African-American Subjects. Am J Geriatr Psychiatr 1997;5:339-343.
  5. The APOE and Alzheimer Disease Meta Analysis Consortium. Effects of Age, Gender and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease. JAMA 1997;278(16):1349-56.
  6. Hendrie HC, Unverzagt FW and Austrom MG. The Dementing Disorders. Psychiatr Q 1997;68(3):261-279.
  7. Hall K, Gureje O, Gao S, Ogunniyi A, Hui SL, Baiyewu O, Unverzagt FW, Oluwole S and Hendrie HC. Risk factors and Alzheimer's disease: a comparative study of two communities. Aust N Z J Psychiatry 1998; 32:698-706.
  8. Gao SJ, Hendrie HC, Hall KS and Hui S. The relationship between age, sex and the incidence of dementia and Alzheimer's disease: A Meta-Analysis. Arch Gen Psychiatr 1998;55:809-815.
  9. Mayeux R, Saunders AM, Shea ST, Mirra S, Evans D, Roses AD, Hyman BT, Crain B, Tang MX, Phelps CH and the Alzheimer's Disease Centers Consortium on APOE and Alzheimer’s Disease. Utility of the Apolipoprotein-E genotype in the diagnosis of Alzheimer's Disease. N Engl J Med 1998; 338(8):506-511.
  10. Oslin D, Atkinson RM, Smith DM, Hendrie HC. Alcohol Related Dementia: Proposed Clinical Criteria. Int J Geriatr Psychiatry 1998; 13:203-212.
  11. Hendrie HC. Epidemiology of Dementia and Alzheimer's Disease. Am J Geriatr Psychiatry 1998;6:S3-S18.
  12. Morgan OS, Eldemire DA, Thesiger CH, Luseko J, Sahota A, Gao S, Hall KS and Hendrie HC. APOE Allele frequencies in demented and nondemented elderly Jamaicans. Ann Neurol 1998; 43(4):545.
  13. Lahiri DK, Xu Y, Klaunig J, Baiyewu O, Ogunniyi A, Hall K, Hendrie H, and Sahota A. Effect of oxidative stress on DNA damage and beta-amyloid precursor proteins in lymphoblastoid cell lines from a Nigerian population. Annals of New York Academy of Sciences 1999; 893:331-336.
  14. Unverzagt FW, Morgan OS, Thesiger CH, Eldemire DA, Luseko J, Pokuri S, Hui SL, Hall KS and Hendrie HC. Clinical utility of CERAD neuropsychological battery in elderly Jamaicans. JINS 1999;5:255-259.
  15. Hendrie HC. Alzheimer's Disease: A Review of Cross-Cultural Studies.  In Epidemiology of Alzheimer Disease: From Gene to Prevention. R. Mayeux (Ed.), Springer-Verlag, Berlin Heidelberg 1999;87-101.
  16. Perkins AJ, Hendrie HC, Callahan CM, Gao S, Unverzagt FW, Xu Y, Hall KS and Hui SL. Association of Antioxidants with Memory in a Multiethnic Elderly Sample Using the Third National Health and Nutrition Examination Survey.  Am J Epidemiol 1999;150:37-44.
  17. Richards S and Hendrie HC.  Diagnosis, management and treatment of Alzheimer's Disease: A Guide for the Internist. Arch Int  Med 1999;159(8):789-798.
  18. Roberts RJ, Musick BS, Olley B, Hall KS, Hendrie HC, Oyediran ABOO. Data management in a longitudinal cross-cultural study. Statistics in Medicine 2000; 19(11-12):1645-1649.
  19. Afolabi I, Asl KH, Nakamura M, Jacobs P, Hendrie H, Benson MD. Transthyretin Isoleucine-122 mutation in African and American Blacks. Amyloid 2000; 7(2):121-125.
  20. Gao S, Hui SL, Hll KS, Hendrie HC.  Estimating disease prevalence from two-phase surveys with nonresponse at the second phase. Statistics in Medicine 2000; 19:2101-2114.
  21. Hendrie HC, Gao S and Baiyewu O. A Comparison of Symptoms of Behavioral Disturbances in Yoruba and African American Demented Individuals.  Int Psychogeriatr 2000; 12(1):403-408.
  22. Richards SS, Emsley CL, Roberts J, Murray MD, Hall K, Gao S and Hendrie HC. The association between vascular risk factor mediating medications and cognition and dementia diagnosis in a community-based sample of African Americans. J of the Am Ger Society 2000; 48:1-7.
  23. Gao S, Dolan N, Hall KS and Hendrie HC. The association of demographic factors and physical illness with personality change in a community sample of elderly non-demented African Americans. The American J of Geriatric Psychiatry 2000; 8(3):209-214.
  24. Hall KS, Gao SJ, Emsley CL, Ogunniyi AO, Morgan O and Hendrie HC. Community Screening Interview for Dementia (CSID) Performance in five disparate study sites. Int J Geriatr Psychiatr 2000; 15:521-531.
  25. Hendrie HC.  Sociocultural Issues in Geriatric Psychiatry.  Chapter in Comprehensive Textbook of Psychiatry, Seventh Edition. HI Kaplan and BJ Sadock (Eds.) Lippincott Williams & Wilkins, 2000, Chapter 51.6, 3161-3163.
  26. Emsley CL, Gao S, Hall KS and Hendrie HC. Estimating odds ratios adjusting for misclassification in Alzheimer’s disease risk factor assessment. Statistics in Medicine 2000; 19:1523-1530.
  27. Emsley CL, Gao SJ, Li Y, Liang C, Ji R, Hall KS, Gao J, Ma F, Wu Y, Ying P, Zhang Y, Sun S, Unverzagt FW, Slemenda CW, and Hendrie HC. Trace element levels in drinking water and cognitive function in elderly Chinese. Am J Epidemiol 2000; 151(9):913-920.
  28. Evans RM, Emsley CL, Gao S, Sahota A, Hall KS, Farlow MR and Hendrie HC. Serum cholesterol, ApoE genotype and the risk for Alzheimer's disease: A population-based study of African Americans. Neurology 2000;54:240-242.
  29. Hall KS, Gao SJ, Unverzagt FW and Hendrie HC. Low Education and Childhood Rural Residence: Risk for Alzheimer's Disease in African Americans. Neurology 2000;54(1):95-99.
  30. Richards S and Hendrie HC.  Diagnosis, management and treatment of Alzheimer's Disease: A Guide for the Internist. Arch Int  Med 1999;159(8):789-798.
  31. Hendrie HC, Ogunniyi A, Hall KS, Baiyewu O, Unverzagt FW, Gureje O, Gao S, Evans RM, Ogunseyinde AO, Adeyinka AO, Musick B, Hui SL. Incidence of dementia and Alzheimer's disease in 2 Communities. JAMA 2001 Feb.; 285(6)739-47.
  32. Hall KS, Hendrie HC. CSID and Culture Fair Cognitive Testing. In Principles and Practice of Geriatric Psychiatry – Second Edition. J. Copeland, M. Abou-Saleh and D. Blazer (eds.). John Wiley & Sons, Ltd., Sussex England (in press).
  33. Stump TE, Callahan CM, Hendrie HC. Cognitive impairment and mortality in older primary care patients. J Am Geriatr Soc 2001;49:934-41.
  34. Unverzagt FW, Gao S, Baiyewu O, Ogunniyi AO, Gureje O, Perkins A, Emsley CL, Dickens J, Evans R, Musick B, Hall KS, Hui SL, Hendrie HC. Prevalence of cognitive impairment: Data from the Indianapolis Study of Health and Aging. Neurology 2001; 57(9):1655-1662.
  35. Ogunniyi A, Baiyewu O, Gureje O, Hall KS, Unverzagt FW, Oluwole SA, Farlow MI, Komolafe, Hendrie HC. Morbidity pattern in a sample of elderly Nigerians resident in Idikan community, Ibadan. West Afr J Med 2001;20(4):227-31.
  36. Perkins AJ, Hui SL, Ogunniyi A, Gureje O, Baiyewu O, Unverzagt FW, Gao S, Hall KS, Musick BS, Hendrie HC. Risk of mortality for dementia in a developing country: the Yoruba in Nigeria. Int J Geriatr Psychiatry 2002;17:566-573.
  37. Callahan CM, Unverzagt FW, Hui SL, Perkins AJ, Hendrie HC. Six-Item Screener to Identify Cognitive Impairment Among Potential Subjects for Clinical Research. Med Care 2002;40(9):771-781.
  38. Ogunnyi A, Akang EE, Gureje O, Takao M, Piccardo P, Baiyewu O, Hall KS, Ghetti B, Hendrie HC. Dementia with Lewy bodies in a Nigerian: a case report. Int Psychogeriatr 2002;14(2):211-8.
  39. Murray MD, Lane KA, Gao S, Evans RM, Unverzagt FW, Hall KS, Hendrie H. Preservation of cognitive function with antihypertensive medications: a longitudinal analysis of a community-based sample of African Americans. Arch Intern Med 2002;162(18):2090-6.
  40. Smith-Gamble V, Baiyewu O, Perkins AJ, Gureje O, Hall KS, Ogunniyi A, Hui SL, Hendrie HC. Informant reports of changes in personality predict dementia in a population-based study of elderly African Americans and Yoruba. Am J Geriatr Psychiatry 2002; 10(6):724-732.
  41. Baiyewu O, Unverzagt FW, Ogunniyi A, Hall KS, Gureje O, Gao S, Lane KA, Hendrie HC. Cognitive impairment in community-dwelling older Nigerians: clinical correlates and stability of diagnosis. Eur J Neurol 2002; 9(6):573-80.
  42. Desai PP, Hendrie HC, Evans RM, Murrell JR, DeKosky ST, Kamboh MI. Genetic variation in apolipoprotein D affects the risk of Alzheimer disease in African-Americans. Am J Med Genet 2003;116(1 Suppl):98-101.
  43. Guerriero Austrom M, Perkins AJ, Damush TM, Hendrie HC. Predictors of life satisfaction in retired physicians and spouses. Soc Psychiatry Psychiatr Epidemiol 2003;38(3):134-41.
  44. Lane KA, Gao S, Hui SL, Murrell JR, Hall KS, Hendrie HC. Apolipoprotein E and mortality in African-Americans and Yoruba. J Alzheimers Dis. 2003;5(5):383-90.
  45. Guerriero Austrom M, Damush TM, Hartwell CW, Perkins T, Unverzagt F, Boustani M, Hendrie HC, Callahan CM. Development and implementation of nonpharmacologic protocols for the management of patients with Alzheimer's disease and their families in a multiracial primary care setting. Gerontologist. 2004 Aug;44(4):548-53.
  46. Callahan CM, Kroenke K, Counsell SR, Hendrie HC, Perkins AJ, Katon W, Noel PH, Harpole L, Hunkeler EM, Unutzer J; for the IMPACT Investigators. Treatment of depression improves physical functioning in older adults . J Am Geriatr Soc. 2005 Mar;53(3):367-73.
  47. Williams LS, Brizendine EJ, Plue L, Bakas T, Tu W, Hendrie H, Kroenke K. Performance of the PHQ-9 as a screening tool for depression after stroke . Stroke. 2005 Mar;36(3):635-8.
  48. Boustani M, Callahan CM, Unverzagt FW, Austrom MG, Perkins AJ, Fultz BA, Hui SL, Hendrie HC. Implementing a screening and diagnosis program for dementia in primary care. J Gen Intern Med. 2005 Jul;20(7):572-7.
  49. Baiyewu O, Unverzagt F, Lane K, Gureje O, Ogunniyi A, Musick B, Gao S, Hall K, Hendrie H. The Stick Design test: A new measure of visuoconstructional ability. J Int Neuropsychol Soc. 2005 Sep;11(5):598-605.
  50. Ogunniyi A, Hall KS, Baiyewu O, Gureje O, Unverzagt FW, Gao S, Hendrie HC. Caring for individuals with dementia: the Nigerian experience. West Afr J Med. 2005 Jul-Sep;24(3):259-62.
  51. Ganguli M, Hendrie HC. Screening for cognitive impairment and depression in ethnically diverse older populations. Alzheimer Dis Assoc Disord. 2005 October/November/December;19(4):275-78.
  52. Hall K, Murrell J, Ogunniyi A, Deeg M, Baiyewu O, Gao S, Gureje O, Dickens J, Evans R, Smith-Gamble V, Unverzagt FW, Shen J, Hendrie H. Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian Yoruba. Neurology. 2006 Jan 24;66(2):223-7.
  53. Hendrie HC, Albert MS, Butters MA, Gao S, Knopman DS, Launer LJ, Yaffe K, Cuthbert BN, Edwards E, Wagster MV. The NIH Cognitive and Emotional Health Project: Report of the Critical Evaluation Study Committee. Alzheimer’s and Dementia: The Journal of the Alzheimer’s Association 2006 Jan; 2(1):12-32.
  54. Gureje O, Ogunniyi A, Baiyewu O, Price B, Unverzagt FW, Evans RM, Smith-Gamble V, Lane KA, Gao S, Hall KS, Hendrie HC, Murrell JR. APOE epsilon4 is not associated with Alzheimer's disease in elderly Nigerians. Ann Neurol. 2006 Jan;59(1):182-5.
  55. Schubert CC, Boustani M, Callahan CM, Perkins AJ , Carney CP, Fox C, Unverzagt F, Hui S, Hendrie HC. Comorbidity profile of dementia patients in primary care: are they sicker? J Am Geriatr Soc. 2006 Jan;54(1):104-9.
  56. Steffens DC, Otey E, Alexopoulos GS, Butters MA, Cuthbert B, Ganguli M, Geda YE, Hendrie HC, et al. Perspectives on depression, mild cognitive impairment, and cognitive decline. Arch Gen Psychiatry. 2006 Feb;63(2):130-8.
  57. Murrell JR, Price B, Lane KA, Baiyewu O, Gureje O, Ogunniyi A, Unverzagt FW, Smith-Gamble V, Gao S, Hendrie HC, Hall KS. Association of apolipoprotein E genotype and Alzheimer disease in African Americans. Arch Neurol. 2006 Mar;63(3):431-4.
  58. Hendrie HC, Lane KA, Ogunniyi A, Baiyewu O, Gureje O, Evans R, Smith-Gamble V, Pettaway M, Unverzagt FW, Gao S, Hall KS.  The development of a semi-structured home interview (CHIF) to directly assess function in cognitively impaired elderly people in two cultures. Int Psychogeriatr. 2006 Apr 26;1-14.
  59. Callahan CM, Boustani MA, Unverzagt FW, Austrom MG, Damush TM, Perkins AJ, Fultz BA, Hui SL, Counsell SR, Hendrie HC. Effectiveness of collaborative care for older adults with Alzheimer disease in primary care: A randomized controlled trial. JAMA. 2006 May 10;295(18):2148-57.
  60. Hendrie HC. Lessons learned from international comparative crosscultural studies on dementia. Am J Geriatr Psychiatry. 2006 Jun;14(6):480-8.
  61. Boustani M, Perkins AJ, Fox C, Unverzagt F, Austrom MG, Fultz B, Hui S, Callahan CM, Hendrie HC.  Who refuses the diagnostic assessment for dementia in primary care? Int J Geriatr Psychiatry. 2006 Jun 16;21(6):556-63.
  62. Shen J, Gao S, Unverzagt FW, Ogunniyi A, Baiyewu O, Gureje O, Hendrie HC, Hall KS. Validation analysis of informant's ratings of cognitive function in African Americans and Nigerians. Int J Geriatr Psychiatry. 2006 Jul;21(7):618-25.
  63. Williams LS, Bakas T, Brizendine E, Plue L, Tu W, Hendrie H, Kroenke K. How valid are family proxy assessments of stroke patients' health-related quality of life? Stroke. 2006 Aug;37(8):2081-5.
  64. Hendrie HC, Murrell J, Gao S, Unverzagt FW, Ogunniyi A, Hall KS. International studies in dementia with particular emphasis on populations of African origin. Alzheimer Dis Assoc Disord. 2006 July/September;20 Suppl 2:S42-S46.
  65. Ogunniyi A, Hall KS, Gureje O, Baiyewu O, Gao S, Unverzagt FW, Smith-Gamble V, Evans RE, Dickens J, Musick BS, Hendrie HC. Risk factors for incident Alzheimer's disease in African Americans and Yoruba. Metab Brain Dis. 2006 Sep;21(2-3):235-40.
  66. Unutzer J, Tang L, Oishi S, Katon W, Williams JW Jr, Hunkeler E, Hendrie H, Lin EH, Levine S, Grypma L, Steffens DC, Fields J, Langston C; for the IMPACT Investigators.  Reducing suicidal ideation in depressed older primary care patients. J Am Geriatr Soc. 2006 Oct;54(10):1550-6.
  67. Guerriero Austrom M, Hartwell C, Moore P, Perkins AJ, Damush T, Unverzagt FW, Boustani M, Hendrie HC, Callahan CM. An integrated model of comprehensive care for people with Alzheimer’s disease and their caregivers in a primary care setting. Dementia. Sage Publications. 2006;5:339-52.
  68. Williams LS, Kroenke K, Bakas T, Plue LD, Brizendine E, Tu W, Hendrie H. Care management of poststroke depression: a randomized, controlled trial. Stroke. 2007 Mar;38(3):998-1003.
  69. Gao S, Jin Y, Hall KS, Liang C, Unverzagt FW, Ji R, Murrell JR, Cao J, Shen J, Ma F, Matesan J, Ying B, Cheng Y, Bian J, Li P, Hendrie HC. Selenium level and cognitive function in rural elderly chinese. Am J Epidemiol. 2007 Apr 15;165(8):955-65.
  70. Boustani M, Hall KS, Lane KA, Aljadhey H, Gao S, Unverzagt F, Murray MD, Ogunniyi A, Hendrie H.  The association between cognition and histamine-2 receptor antagonists in african americans. J Am Geriatr Soc. 2007 Aug;55(8):1248-53.
  71. Baiyewu O, Smith-Gamble V, Lane KA, Gureje O, Gao S, Ogunniyi A, Unverzagt FW, Hall KS, Hendrie HC. Prevalence estimates of depression in elderly community-dwelling African Americans in Indianapolis and Yoruba in Ibadan, Nigeria. Int Psychogeriatr. 2007 Aug;19(4):679-89.
  72. Unverzagt FW, Sujuan Gao, Lane KA, Callahan C, Ogunniyi A, Baiyewu O, Gureje O, Hall KS, Hendrie HC. Mild cognitive dysfunction: an epidemiological perspective with an emphasis on african americans. J Geriatr Psychiatry Neurol. 2007 Dec;20(4):215-26.
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