Smith-Gamble V, Baiyewu O, Perkins AJ, Gureje O, Hall KS, Ogunniyi A, Hui SL, Hendrie HC. Informant reports of changes in
personality predict dementia in a population-based study of elderly African Americans and Yoruba. Am J Geriatr Psychiatry 2002;
10(6):724-732.
OBJECTIVE: The authors conducted a longitudinal, population-based survey of African Americans in Indianapolis, Indiana,
and Yoruba in Ibadan, Nigeria, using the Community Screening Interview for Dementia to assess the predictive value of
informant reports of changes in personality on incident dementia and Alzheimer disease.
METHODS: In all, 3,021 subjects had informants' reports of changes in personality and dementia status (2,084 subjects residing
in Ibadan and 937 subjects residing in Indianapolis).
RESULTS: After adjusting for demographic, cognitive, and functional characteristics in two markedly different populations,
socioeconomically and culturally, subjects with changes in personality had approximately twice the odds of having dementia
as subjects with no change in personality.
CONCLUSION: The finding that in two markedly different populations, personality change is a significant predictor of future
dementia, independent of cognition and functional status, should make clinicians particularly sensitive to these reports when
they occur in their elderly patients.
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